1. Evolutionary genomics of epidemic visceral leishmaniasis in the Indian ...
22 mrt 2016 · Imamura et al.'s study reveals how L. donovani has spread throughout the Indian subcontinent in fine detail. The genome data can be used to ...
The parasite Leishmania donovani causes a disease called visceral leishmaniasis that affects many of the world's poorest people. Around half a million new cases develop every year, but health authorities lack safe and effective drugs to treat them. Up to 80% of these cases occur in the Indian subcontinent, where devastating epidemics have occurred in the last decades. One reason these epidemics continue to occur is that the parasites develop genetic mutations allowing them to adapt to and resist the drugs used to kill them. As there are few existing drugs that can kill L. donovani, it is crucial to understand how drug resistance emerges and spreads among parasite populations. Imamura, Downing, Van den Broeck et al. have now investigated the history of visceral leishmaniasis epidemics by characterising the complete genetic sequence – or genome – of 204 L. donovani parasite samples. This revealed that the majority of parasites in the Indian subcontinent first appeared in the nineteenth century, matching the first historical records of visceral leishmaniasis epidemics. The genomes show that most of the parasites are genetically similar and can be clustered into several closely related groups. These groups first appeared in the 1960s following the end of a regional campaign to eradicate malaria. The most common parasite group is particularly resistant to drugs called antimonials, which were the main treatment for leishmaniasis until recently. These parasites have a small genetic...
2. A case of hemangiopericytoma of the cheek in a child - J-Stage
The tumor was excised with the skin and oral mucosa. As of 20 months after the operation, the patient has remained free of recurrence and metastasis. However, ...
A case of hemangiopericytoma of the cheek in a 5 -year-old child is reported. Twenty-two cases of this tumor in the oral and maxillofacial region have …
3. Hideo Imamura - Vrije Universiteit Brussel
Bevat niet: surgery | Resultaten tonen met:surgery
Dive into the research topics where Hideo Imamura is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
4. Japanese Journal of Oral and Maxillofacial Surgery - J-Stage
Nami JOZAKI, Nobuhiro NOGUCHI, Hideo IMAMURA, Eiro KUBOTA, Masaaki GOT ... ... Non-surgical treatment was used mainly in patients without severe fracture line ...
Published by Japanese Society of Oral and Maxillofacial Surgeons. FREE ACCESS
5. Weak preservation of local neutral substitution rates across ...
5 mei 2009 · The correlations that do persist are too weak to be responsible for many of the highly conserved elements found by phylogenetic footprinting ...
The rate at which neutral (non-functional) bases undergo substitution is highly dependent on their location within a genome. However, it is not clear how fast these location-dependent rates change, or to what extent the substitution rate patterns are conserved between lineages. To address this question, which is critical not only for understanding the substitution process but also for evaluating phylogenetic footprinting algorithms, we examine ancestral repeats: a predominantly neutral dataset with a significantly higher genomic density than other datasets commonly used to study substitution rate variation. Using this repeat data, we measure the extent to which orthologous ancestral repeat sequences exhibit similar substitution patterns in separate mammalian lineages, allowing us to ascertain how well local substitution rates have been preserved across species. We calculated substitution rates for each ancestral repeat in each of three independent mammalian lineages (primate – from human/macaque alignments, rodent – from mouse/rat alignments, and laurasiatheria – from dog/cow alignments). We then measured the correlation of local substitution rates among these lineages. Overall we found the correlations between lineages to be statistically significant, but too weak to have much predictive power (r2 <5%). These correlations were found to be primarily driven by regional effects at the scale of several hundred kb or larger. A few repeat classes (e.g. 7SK, Charlie8, and MER121...
6. [PDF] Haplotype selection as an adaptive mechanism in the protozoan ...
23 apr 2019 · ... Hideo Imamura, et al.. Hap- lotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani. Nature. Ecology ...
7. Pathogenesis of acute gastroesophageal reflux disease ...
31 okt 2016 · Naoya Yoshida, Yu Imamura, Yoshifumi Baba, Hideo Baba. Department of Gastroenterological Surgery, Graduate School of Medical Sciences ...
Pathogenesis of acute gastroesophageal reflux disease might be changing
8. Asian Journal of Oral and Maxillofacial Surgery | Scholars Portal ...
No search limits have been applied. Current ... Immunoreactivity was evaluated ... My Articles ... Hideo Imamura · Masaaki Goto · Takeshi Katsuki. Source ...
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